Molecular crystals: crystal symmetry, close packing, Kitaigorodsky coefficient, structure and conformation of molecules. Molecular interactions in solid state: Van der Waals forces, polar interactions, hydrogen bonds, halogen bonds. Topology of molecular interactions and topologic descriptors. Crystallisation: oversaturation and metastable state, nucleation, crystal growth, methods of crystallisation. Polymorphism: thermodynamic and kinetic control, polymorph nucleation, phase rule, metastable form, physical and chemical properties of polymorphs. Isomorphous, amorphous and isostructural compounds. Multicomponent systems: solvates, salts, cocrystals, physical and chemical properties, application. Solid state reactions: mechanochemical synthesis (neat and liquid-asisted grinding), microwave-assisted synthesis, photochemical synthesis and single-crystal-to-single-crystal reactions.
1. To compare and to contrast the difference between ionic, covalent and molecular crystals.
2. To classify molecular interactions in the solid state.
3. To explain the topology of molecular interactions and topologic descriptors.
4. To define the terms: hydrate, solvate, salt, cocrystal.
5. To classify and to explain methods for crystallization of molecular crystals from solution.
6. To explain the terms polymorphism and isomorphism.
7. To classify and to explain methods of the mechanochemical synthesis in the solid state.
8. To compare and to contrast the difference between covalent and supramolecular mechanosynthesis.
9. To describe the terms: reaction without solvents, aging reaction, grinding reaction.
10. To give a short oral lecture on given subject.
- 1. D. Braga i F. Grepioni, Making Crystals by Design: Methods, Techniques and Applications, Wiley-VCH, Weinheim, 2007.
2. G. S. Rohrer, Structure and Bonding in Crystalline Materials, Cambridge Univ. Press, Cambridge, 2006.
3. G. R. Desiraju, Crystal Engineering: The Design of Organic Solids, Elsevier, Amsterdam, 1989.