A Research Paper Published in the...

A researcher from the Department of Chemistry Predrag Novak and a PhD student Ivana Rubić, collaborating with Josipa Kuleš, Renata Barić Rafaj, Tomislav Mašek and Vladimir Mrljak from the Faculty of Veterinary Medicine, University of Zagreb, Anita Horvatić from the Faculty of Food Technology and Biotechnology, University of Zagreb as well as Richard Burchmore, Stefan Weidt, Clement Regnault and Peter David Eckersall from the University in Glasgow, have published a paper "Multi Platforms Strategies and Metabolomics Approaches for the Investigation of Comprehensive Metabolite Profile in Dogs with Babesia canis Infection", in International Journal of Molecular Sciences (IF = 5.924).

Canine babesiosis is an important tick-borne disease worldwide, caused by parasites of the Babesia genus. The goal of the study was to explore and characterize the serum metabolome, by identifying potential metabolites and metabolic pathways in dogs naturally infected with Babesia canis using liquid and gas chromatography coupled to mass spectrometry. The study confirmed that host–pathogen interactions could be studied by metabolomics to assess chemical changes in the host, such that the differences in serum metabolome between healthy dogs and those with B. canis infection, can be detected with liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS) methods. The study has provided novel insight into the pathophysiological mechanisms of B. canis infection.

Author: Adriana Kenđel
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