Title: | Associate Professor |
Location: | 123 |
Public phone number: | +385 1 4606 195 |
Internal phone number: | 6195 |
E-mail: | |
Department: | Division of Analytical Chemistry |
Graduation year: | 2008 |
PhD graduation year: | 2013 |
Employed in this institution since: | 2009 |
integrated undergraduate and graduate
doctoral
Education at Department of Chemistry, Faculty of Science, University of Zagreb: Diploma thesis (Chemistry, 2008); Doctoral thesis (Chemistry, Analytical Chemistry, 2013).
Affiliation and current position: Division of Analytical Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb: Associate Professor (2023–)
Previous positions: Assistant Professor (2016–2023); Senior Assistant (2014–2016); Assistant (2009–2014), Division of Analytical Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb.
Visits to foreign research and education institutions: CEEPUS Scholarship - University in Pecs, Faculty of Sciences, Institute of Chemistry, Department of Inorganic Chemistry, Pecs, Hungary; Scholarship of the Scholarship foundation of the Republic of Austria, Graz University of Technology (TU Graz), Institute for Process and Particle Engineering, Graz, Austria, 01.02.– 31.05.2012; Research Stay for University Academics, Technical University Munich (TU München), Department of Chemistry, Chair for Biomolecular NMR Spectroscopy, Munich, Germany, 15.09.-15.12.2016; EMBO Short-Term Fellowship - Nanyang Technological University (NTU Singapore), School of Physical & Mathematical Sciences, Singapore, 30.11.2019–27.02.2020
Research interest: synthesis and structure elucidation of bioactive compounds (macrolide antibiotics, peptide nucleic acids, metabolites and small organic ligands); biomolecular interaction studies; complex mixture analysis; development of process analytical techniques (PAT) based on in-line vibrational spectroscopy; identification of polymorphic forms of bioactive compounds by combining spectroscopic (solid-state NMR, Raman, IR) and SWAXS methods.
Scientific papers: co-author of 23 scientific papers in journals indexed in Web of Science database, 2 book chapters, 2 student scripts and 1 university textbook
Awards and recognitions and memberships: Recognition for achievements in scientific and professional work at the Faculty of Science, 2015; Member of the Croatian Chemical Society; Member of the Croatian Society of Chemical Engineers
Participation in research projects:
Investigation of macrolide antibiotic metabolites and degradation products (project leader); bilateral Croatian-Austrian project funded by the Government of the Republic of Croatia and the Austrian Federal Government; period: 01.01.2018–31.12.2019
Macrozones, new conjugates of macrolide antibiotics: design, synthesis and interactions; funded by Croatian Science Foundation; project No. 8098; period: 01.10.2018–30.09.2022
Interactions and design of bioactive molecules; funded by Ministry of Science, Education and Sports of the Republic of Croatia; project No. 119-11913 42-1083; period: 02.01.2007–31.12.2013
Development and application of an in-line method of Raman spectroscopy for drug research; funded by Croatian Science Foundation and PLIVA Hrvatska d.o.o.; period: 01.04.2008–01.04.2010
Macrolide-ribosome interactions monitored by NMR paramagnetic relaxation enhancements; bilateral Croatian-Austrian project funded by the Government of the Republic of Croatia and the Austrian Federal Government; period: 01.01.2010– 31.12.2011
Investigating macrolide antibiotic interactions with membranes and ribosomes as a tool for rational drug design; bilateral Croatian-Austrian project funded by the Government of the Republic of Croatia and the Austrian Federal Government; period: 01.01.2012– 31.12.2013
The development of a new methodology for the control of drug preparation process – Met4Pharm; funded by European Regional Development Fund and Croatian State Budget; period: 22.10.2014–22.02.2016
DOSY NMR spectroscopy for complex mixture analysis
Deep reinforcement learning classification of sparkling wines based on ICP-MS and DOSY NMR spectra
Analysis of Croatian and Slovenian sparkling wines by NMR spectroscopy
Antimicrobial macrozones interact with biological macromolecules via two-site binding mode of action: Fluorimetric, NMR and docking studies
Deep reinforcement learning classification of sparkling wines based on ICP-MS and DOSY NMR spectra
Sustainable hydrothermal co-carbonization of residues from the vegetable oil industry and sewage sludge: Hydrochar production and liquid fraction valorisation
NMR and fluorometric studies of bioactive macrozone interactions with their biological targets
Prediction of environmental microbial biotransformation of azithromycin, its thiosemicarbazone conjugates and their precursors
Interactions of 4“-pyridine-3-yl- and 4“-(4-trifluoromethoxyphenyl)- macrozones with biological targets
Analysis of raw cow's milk sampled in different stages of mastitis by applying 1H and DOSY NMR techniques
Design, preparation and characterization of 7-hydroxy-4-methylcoumarin-based deep eutectic solvents
Application of nmr spectroscopy and statistical analysis in characterization of crude oil samples
Interaction studies of new bioactive macrolide derivatives with bacterial ribosome
STRUCTURE AND INTERACTIONS OF AZITHROMYCIN- THIOSEMICARBAZONE CONJUGATES AS SEEN BY NMR
Prediction of Environmental Microbial Degradation of Azithromycin in Soil and Water and Metabolism in Humans
Improvement of the Nutraceutical Profile of Brewer’s Spent Grain after Treatment with Trametes versicolor
Inclusion of CO2, NH3, SO2, Cl2 and H2S in porous N4O4-donor macrocyclic Schiff base
Interactions of macrozones with their biological receptors
Study of interactions between clarithromycin and ribosome isolated from Escherichia coli by NMR spectroscopy
Synthesis and characterization of macrozones, novel bioactive derivatives of azithromycin
Structure characterization of aminopropyl azithromycin derivatives in solution and solid state
NMR methods for studying structure and interactions of macrozones
Interactions of aminopropyl–azithromycin derivatives, precursors in the synthesis of bioactive macrozones, with E. coli ribosome: NMR and docking studies
Machine learning approach for predicting crude oil stability based on NMR spectroscopy
Interactions of azithromycin aminopropyl derivatives with E. coli ribosome studied by NMR spectroscopy
Magnetic field influence on asphaltene aggregation monitored by diffusion NMR spectroscopy: Is aggregation reversible at high magnetic fields?
Solution and solid state studies of hydrogen bonding in substituted oxazolidinones by spectroscopic and quantum chemical methods
Synthesis, structure characterization and interactions of 4“-aminopropyl derivative of azithromycin
Structural studies of substituted oxazolidinones by spectroscopic and quantum chemical methods
Analysis of crude oil samples of different api density by one- and two-dimensional NMR spectroscopy
Advanced Methods for Studying Structure and Interactions of Macrolide Antibiotics
Correlations between structural and stability parameters of crude oils and their heavy fractions
Domestic crude oil characterization by elemental analysis and NMR spectroscopy
Structure characterisation of bioactive compounds and their interactions
Epitope mapping of a macrozone interaction with ribosome by NMR spectroscopy and molecular modeling
Structural basis for lipid interactions with glutathione peroxidase 4
LC-SPE/NMR analysis of macrozones, new bioactive azithromycin conjugates
Correlations between structural and stability parameters of crude oils and their heavy fractions
Influence of paramagnetic metals on the asphaltene aggregation behavior
Magnetic Field Influence on Asphaltene Aggregation Observed by DOSY NMR
Synthesis and characterization of macrozones, new bioactive azithromycin conjugates
NMR and Docking Studies of Novel Macrolide Conjugates
NMR Spectroscopy as a Tool for Studying Asphaltene Composition
Monitoring concentration and magnetic field influence on asphaltene aggregation by NMR spectroscopy
Impurity profiling of azithromycin conjugates by LC- SPE/CRYO NMR methodology
Concentration dependence of asphaltene aggregation monitored by DOSY NMR
Characterisation of asphaltenes by DOSY NMR spectroscpy
Monitoring of omeprazole synthesis by hyphenated LC-SPE/NMR system
DOSY NMR spectroscopy in the analysis of complex oil mixtures
Investigation of asphaltene aggregation in heavy oil samples using DOSY NMR spectroscopy
Intriguing binding modes of tetradentate pyridoxal derivatives to molybdenum centre
Osnovni priručnik za rad sa spektrometrom NMR visoke rezolucije
Extraction and characterization of the cellulose and lignin from the plant Miscanthus giganteus
Multiple crystalline forms of 1,5- bis(salicylidebne)carbohydrazide
LC-SPE (cryo)NMR approach to the impurity profiling of 7-ethyltryptophol
Monitoring and quantification of omeprazole synthesis reaction by in-line Raman spectroscopy and characterization of the reaction components
NMR characterisation of 1, 5- bis(salicylidene)carbohydrazide in solution and solid state
Intra- and intermolecular hydrogen bonding in acetylacetone and benzoylacetone derived enaminone derivatives
Rapid identification of bioactive carbohydrazide reaction products by an LC-DAD-SPE-NMR approach
In-line monitoring of API synthesis and product characterisation
Phenylenediamine derivatives of dehydroacetic acid: synthesis, characterisation and deuterium isotope effects
LC-NMR analysis of impurities in a key starting material of Etodolac
On-line and off-line NMR and LC-NMR identification of carbohydrazide derivatives in the reaction mixtures
Pyridoxal hydrazonato molybdenum(VI) complexes : assembly, structure and epoxidation (pre)catalyst testing under solvent-free conditions
NMR and quantum chemical studies of hydrogen bonding in acetylacetone and benzoylacetone derived enaminones
Multiple solid forms of 1, 5-bis(salicylidene)carbohydrazide : polymorph-modulated thermal reactivity
The use of vibrational spectroscopy as a tool for in-line process monitoring
Condensation reaction between carbohydrazide and salicylaldehyde: in-line vibrational spectroscopy monitoring and characterization of the reaction products in solution and solid state
In situ monitoring of condensation reaction between carbohydrazide and salicylaldehyde and characterization of the reaction products
Fast real-time monitoring of entacapone crystallization and characterization of polymorphs via Raman spectroscopy, statistics and SWAXS
Strukturna analiza spojeva spektroskopskim metodama
NMR and DFT study of Hydrogen Bonding in Mono(salicylidene)carbohydrazide
Process Analytical Techniques Based on In-Line Vibrational Spectroscopy and their Industrial Applications
In-line and off-line characterization of entacapone crystallization
Development of in-line vibrational spectroscopy methodology for monitoring of chemical reactions and crystallization of bioactive molecules
Synthesis, structural characterization and hydrogen bonding of mono(salicylidene)carbohydrazide
Determination of crystallization temperature of entacapone using in-line Raman spectroscopy
In-line reaction monitoring of entacapone synthesis by Raman spectroscopy and multivariate analysis
Spektroskopska strukturna analiza
Monitoring of entacapone synthesis reaction by "in-line" Raman spectroscopy and multivariate analysis
Synthesis and characterization of deuterated isotopomers of bioactive phenylenediamine derivatives of 3-acetyl-4-hydroxy-6-methyl-2H- pyran-2-dione
Bioactive Phenylenediamine Derivatives of Dehydroacetic Acid : Synthesis, Structural Characterization and Deuterium Isotope Effects
NMR Spectroscopy for studying interactions of bioactive molecules
Crystallization of 2-cijano-3-(3, 4-dihidroksi-5 nitrofenil)-N, N-dietilprop-2-enamida and characterization of polomorphs using in-line Raman spectroscopy
Praćenje kristalizacije polimorfa entakaponea pomoću Ramanove spektroskopije in line
In-situ Raman spectroscopy for the in-line crystallization monitoring of entacapone
Syntesis and characterization of deuterated isotopomers of ortho-, meta and para- phenylenediamine derivatives of 3-acetyl-4- hydroxy-6-methyl-2h-pyran-2-one
Hydrogen Bonding and Deuterium Isotope Effects in 13C NMR Spectra of Phenylene Enaminones Derived from Dehydroacetic Acid