About employee

dr. sc. Igor Živković

Title: Senior research assistant
Location: 312/ZBK
Public phone number:+385 1 4606 234
Internal phone number:6234
E-mail: E-mail
Personal web page: http://gruic.chem.pmf.unizg.hr/people/phd/#zivkovic
Department: Division of Biochemistry
Graduation year:2016
PhD graduation year:2021
Employed in this institution since:2016

Biography

Education at the Department of Chemistry, Faculty of Science, University of Zagreb: Bachelor's degree in Chemistry (2014), Master's degree in Chemistry (2016), PhD in Chemistry (2021).

Affiliation and current position: Division of Biochemistry, Department of Chemistry, Faculty of Science, University of Zagreb: Research Assistant (2016 - 2022), Postdoc (2022 - ).

Teachings: General biochemistry (seminars) and Biochemistry laboratory (practicum courses).

Research interest: Reaction of aminoacyl-tRNA synthetases with natural and synthetic non-cognate substrates, substrate specificity, kinetics

Memberships: Member of the Croatian Chemical Society Croatian Society of Biochemistry and Molecular Biology.

Published papers recorded in the Croatian Scientific Bibliography Database

Kinetic characterization of amino acid activation by aminoacyl‐tRNA synthetases using radiolabelled γ‐[32P]ATP

Živković, Igor; Dulic, Morana; Kozulic, Petra; Mocibob, Marko; Gruic‐Sovulj, Ita
2024.
FEBS Open Bio

HOW DID NEGATIVE CATALYSIS TAILOR THE SPECIFICITY OF ISOLEUCYL-tRNA SYNTHETASES’S EDITING DOMAIN?

Živković, Igor; Maršavelski, Aleksandra; Gruić-Sovulj, Ita
2024.

Exploring mechanisms of mupirocin resistance and hyper-resistance

Zivkovic, Igor; Gruic-Sovulj, Ita
2024.
Biochemical Society transactions

Negative catalysis by the editing domain of class I aminoacyl-tRNA synthetases

Živković, Igor ; Ivković, Kate ; Cvetešić, Nevena ; Maršavelski, Aleksandra ; Gruić Sovulj, Ita
2022.
Nucleic acids research

ALL BUT ONE: HOW NEGATIVE CATALYSIS SHAPED EVOLUTION OF THE ISOLEUCYL-TRNA SYNTHETASE'S EDITING DOMAIN

Živković, Igor ; Maršavelski, Aleksandra, Gruić- Sovulj, Ita
2022.

Mechanism of discrimination of isoleucyl-tRNA synthetase against nonproteinogenic a- aminobutyrate and its fluorinated analogues

Živković, Igor ; Moschner, Johann ; Koksch, Beate ; Gruić Sovulj, Ita
2020.
The FEBS journal

On the Mechanism and Origin of Isoleucyl-tRNA Synthetase Editing against Norvaline

Biluš, Mirna ; Šemanjski, Maja ; Močibob, Marko ; Živković, Igor ; Cvetešić, Nevena ; Tawfik, Dan ; Toth-Petroczy, Agnes ; Maček, Boris ; Gruić-Sovulj, Ita
2019.
Journal of molecular biology

Maintaining the protein biosynthesis fidelity by isoleucyl-tRNA synthetase

Močibob, Marko ; Biluš, Mirna ; Šemanjski, Maja ; Živković, Igor ; Cvetešić, Nevena ; Maček, Boris ; Gruić Sovulj, Ita
2019.

Trimming a branch: norvaline is more toxic than valine in isoleucine mistranslation

Biluš, Mirna ; Šemanjski, Maja ; Močibob, Marko ; Živković, Igor ; Cvetešić, Nevena ; Tawfik, Dan ; Toth-Petroczy, Agnes ; Gruić-Sovulj, Ita
2018.

Kinetic Origin of Substrate Specificity in Post-Transfer Editing by Leucyl-tRNA Synthetase

Dulić, Morana ; Cvetešić, Nevena ; Živković, Igor ; Palencia, Andrés ; Cusack, Stephen ; Bertoša, Branimir ; Gruić-Sovulj, Ita
2018.
Journal of molecular biology

Exclusion of the cognate substrate from the leucyl - tRNA synthetase editing pathway

Živković, Igor ; Dulić, Morana ; Cvetešić, Nevena ; Bertoša, Branimir ; Gruić-Sovulj, Ita
2017.
More information about publications

List of select publications

1. Živković I., Ivković K., Cvetešić N., Maršavelski A., Gruić Sovulj I., Negative catalysis by the editing domain of class I aminoacyl-tRNA synthetases; Nucleic Acids Research, 50 (2022) 4029-4041. (IF = 16,971); doi:10.1093/nar/gkac207

2. Živković I., Moschner J., Koksch B., Gruić Sovulj I., Mechanism of discrimination of isoleucyl-tRNA synthetase against nonproteinogenic α-aminobutyrate and its fluorinated analogues; The FEBS Journal, 287 (2020) 800-813. (IF = 5,542); doi:10.1111/febs.15053

3. Biluš M., Šemanjski M., Močibob M., Živković I., Cvetešić N., Tawfik D., Toth-Petroczy A., Maček B., Gruić Sovulj I., On the mechanism and origin of isoleucyl-tRNA synthetase editing against norvaline, Journal of Molecular Biology, 431 (2019) 1284-1297. (IF = 5,469); doi:10.1016/j.jmb.2019.01.029

4. Dulić M., Cvetešić N., Živković I., Palencia A., Cusack S., Bertoša B., Gruić Sovulj I., Kinetic origin of substrate specificity in post-transfer editing by leucyl-tRNA synthetase, Journal of Molecular Biology, 430 (2018) 1-16. (IF = 5,469); doi:10.1016/j.jmb.2017.10.024