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Development of the Most Effective Drugs

Code: 152821
ECTS: 5.0
Lecturers in charge: prof. dr. sc. Ines Primožič
Take exam: Studomat

1. komponenta

Lecture typeTotal
Lectures 15
* Load is given in academic hour (1 academic hour = 45 minutes)
Principles of medicinal chemistry. Receptors and drug action:drug-receptor interactions, ion channels, G-protein-coupled receptors, nuclear receptors, protein kinases, intracellular receptors for gene transcription regulation, antibacterial inhibitors of protein synthesis, enzymes as drug targets. Strategies in drug discovery: natural product as a source for new drugs, existing drugs as a basis for new drugs, disease models as screens for new drugs, rational approach in drug design, bioisosterism, prodrugs.
Development of the most effective drugs. Inhibitors of prostaglandin synthetase: analgetics and antiinflamatorics, inhibitors of angiotensin converting enzyme (ACE): antihipertensive agents, calcium chanel blockers, drugs for the treatment of angina and hypertension, antagonists of histamine receptors (H2) as anti-ulcer drugs, proton pump inhibitors and gastric acid secretion inhibitors, antidepressants based on serotonine modifications, ligands for benzodiazepine receptors: hypnotic, anxiolytic, anticonvulsant and muscle relaxant agents, antagonists of histamine receptors (H1): drugs for the treatment of allergic rhinitis, nucleoside analogues inhibitors of HIV reverse transcriptase as drugs for the treatment of AIDS, fluoroquinolones as antibacterial DNA gyrase inhibitors
    R. B. Silverman, M. W. Holladay, The Organic Chemistry of Drug Design and Drug Action, 3rd Edition, Academic Press, San Diego, 2014.
    C. Wermuth, D. Aldous, P. Raboisson, D. Rognan, Editors: The Practice of Medicinal Chemistry 4th Edition, Academic Press, 2015.
    M. Mintas, S. Raić-Malić i N. Raos, Principles of Drug Design, Zagreb, Hinus, 2000.
    N. Raos, S. Raić-Malić i M. Mintas, Drugs in the space-pharmacophores and receptors, Školska knjiga, Zagreb, 2005.
    revijalni članci i znanstvene monografije
Consultations schedule: