| Title: | Associate Professor |
| Location: | 214 |
| Public phone number: | +3851 460 6157 |
| Internal phone number: | 6157 |
| E-mail: | |
| Department: | Division of Physical Chemistry |
| Graduation year: | 2006 |
| PhD graduation year: | 2012 |
| Employed in this institution since: | 2007 |
undergraduate
graduate
integrated undergraduate and graduate
doctoral
Education at Department of Chemistry, Faculty of Science, University of Zagreb: Diploma thesis (Chemistry, 2007); Doctoral thesis (Chemistry, Physical Chemistry, 2012).
Affiliation and current position: Division of Physical Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb: Associate Professor (2021–)
Previous positions:
Assistant Professor (2015–2021), Division of Physical Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb.
Senior Assistant (2013–2015), Division of Physical Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb.
Assistant (2007 – 2013), Division of Physical Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb.
Scientific Research Activities: The scientific activity is focused on the thermodynamic and kinetic investigation of processes in solution, primarily concerning the complexation reactions of macrocyclic ligands (cyclopeptides and calixarenes) with inorganic and organic ions. Current research focuses on linear and cyclic peptides with a small number of subunits and their ion-receptor properties. Additionally, methods for the cyclization of linear peptides are explored, utilizing template anions for the preorganization of the peptide chain in solution.
An integrated approach is applied in these studies, employing spectrophotometric, fluorimetric, CD (circular dichroism), microcalorimetric, and NMR titrations, as well as molecular dynamics simulations, to provide a detailed macroscopic and microscopic description of the complexation process. Thermodynamic research also includes the study of the complexation of polycationic organic receptors with deoxyribonucleic acid (DNA) molecules.
A significant contribution has been made to the construction of an adiabatic calorimeter for dissolving solids and the development of a new method for processing calorimetric data. Kinetic studies are directed toward the spectroscopic investigation of the kinetics and mechanisms of the complexation of organic ligands with transition metal cations in solution.
Scientific papers: co-author of 30 scientific papers in journals indexed in Current Contents database, 1 professional paper. CroRIS - CROSBI
Awards and recognitions and memberships: Rector's award of the University of Zagreb for the year 2003/2004 and The Annual award of The society of university teachers, scholars and other scientists – Zagreb for the year 2013. Member of the Croatian Chemical Society and Croatian Biophysical Society.
Participation in research projects:
Project participant :
HRZZ - Croatian Science Foundation:"Thermodynamic, spectroscopic, and structural aspects of calixarene coordination reactions (CalixCore)" (2024-). (PI: prof. dr. sc. V. Tomišić)
HRZZ - Croatian Science Foundation:"Coordination reactions of macrocyclic ligands in solution (MacroSol)" (2019-2023). (PI: prof. dr. sc. V. Tomišić)
HRZZ - Croatian Science Foundation:"Development of Supramolecular Receptors for Cations and Anions (SupraCAR)" (2015-2019). (PI: prof. dr. sc. V. Tomišić)
Ministry of Science, Republic of Croatia: "Met4Pharm" (2014-2016). (PI: prof. dr. sc. P. Novak)
Ministry of Science, Republic of Croatia: "Electrolytes and Coordination Reactions in Solution" (2007-2013). (PI: prof. dr. sc. V. Tomišić)
Project leader:
2025.
HRZZ - Croatian Science Foundation:"Cyclopeptide complexes with functional ions (CPepFunxIon)"
2021.
Croatian Academy of Sciences and Arts:
Amide calixarene derivatives as versatile binders of cations in solution;
2019.–2020.
Croatian Academy of Sciences and Arts:
Template-assisted peptide cyclization in solution;
2018.–2019.
Croatian Academy of Sciences and Arts:
Thermodynamic and structural investigation of cyclopeptide complexation with halogen and structural anions in solution;
1. T. Rinkovec, S. Tarana, M. Modrušan, N. Vidović, A. Tomić, N. Cindro, G. Speranza, V. Tomišić, G. Horvat, Anion complexes of small Boc-protected lysine cyclopeptides in solution, J. Mol. Liq. 433 (2025) 127837.
2. M. Modrušan, L. Glazer, L. Otmačić, I. Crnolatac, N. Cindro, N. Vidović, I. Piantanida, G. Speranza, G. Horvat, V. Tomišić, Anion-Binding Properties of Short Linear Homopeptides, Int. J. Mol. Sci. 25 (2024) 5235.
3. I. Petters, M. Modrušan, N. Vidović, I. Crnolatac, N. Cindro, I. Piantanida, G. Speranza, G. Horvat, V. Tomišić, Anion-Sensing Properties of Cyclopentaphenylalanine, Molecules 27 (2022) 3918.
4. G. Horvat, M. Kveder, J. You, Inter-pulse delay optimization for dynamical decoupling pulse sequences with up to six refocusing pulses, Eur. Phys. J. Plus 136 (2021) 842.
5. G. Horvat, S. Tarana, N. Vidović, N. Cindro, G. Speranza, V. Tomišić, Thermodynamic and MD studies of anion complexation by cyclopentaleucine in acetonitrile and dimethyl sulfoxide, J. Mol. Liq. 340 (2021) 116848.
6. Vidović, Nikolina; Horvat, Gordan; Riva, Davide; Rinkovec, Tamara; Cindro, Nikola; Tomišić, Vladislav; Speranza, Giovanna, Chloride-Assisted Peptide Macrocyclization, Org. Lett., 22 (2020), 2129-2134.
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