1. komponenta

Lecture type	Total
Lectures	15
Practicum	15
Seminar	15

* Load is given in academic hour (1 academic hour = 45 minutes)

LEARNING OUTCOMES:
Identification and acceptance of practical knowledge in toxicity testing of toxic substances and drugs, understanding of physiological processes important for analysis of toxicity data
Course themes:
1. Experimental in vivo and in vitro models in toxicology; 2.RRR principle, 3; Enzymes and biochemical pathways in toxicologic pathophysiology; 4. Standards and directives in toxicity testing, 5. Experimental design, 6. Drug toxicity testing, 7. Dose, 6. Biotransformation, 7. Apsorption, distribution, bioaccumulation, 8. citostatic drugs, 9. Nephrotoxicity, 10. Immunotoxicity, 10. Neurotoxicity, 11. Endocrine disruption, 12. Comparative toxicological models 13. Specific and systemic toxicity, 14. Toxicity of Mixtures, 15 major clases of xenobiotics

1. Principles and Methods of Toxicology, Fifth Edition by A. Wallace Hayes (2007)
2. Introduction to Toxicology, Third Edition by John A. Timbrell (2001)

Izborni kolegiji - Regular - Physiology and Immunobiology