prof. dr. sc. Ivana Ivančić Baće

Teaching

undergraduate

• Molecular Genetics (40885) - Lecturer in charge

graduate

• Molecular Genetics (44030) - Lecturer in charge
• Molecular Genetics (246023) - Lecturer in charge

integrated undergraduate and graduate

• Fundamentals of Molecular Biology (37582) - Lecturer in charge
• Molecular Biology and Biotechnology (196128) - Lecturer in charge

doctoral

• Genetic Recombination and DNA Repair (151788) - Lecturer in charge

Biography

DATE AND PLACE OF BIRTH:

July 1st, 1973 in Zenica, Bosnia and Herzegovina, where I completed elementary and high school education

EDUCATION:

1992-1997    Molecular biology study, Faculty of Science, The University of Zagreb, diploma thesis received on January 15th 1997
1997-2000    Postgraduate study, Faculty of Science, The University of Zagreb,  and     research toward M. Sc.
2000    M. Sc. degree
2000-2001    Fellowship in the Professor's Lloyd laboratory, Institute of Genetics, The University of Nottingham, United Kingdom
2004        PhD degree in biology

POSITIONS HELD:

1997-2000    Research and young teaching assistant at the Department of Molecular Biology, Faculty of Science, The University of Zagreb, the molecular genetics course where I'm in charge of laboratory and seminar education
2000-2004    Research and teaching assistant at the Department of Molecular Biology, Faculty of Science, The University of Zagreb
2004-2008    Research and senior teaching assistant at the Department of Molecular Biology, Faculty of Science, The University of Zagreb
2008-2017    Assistant professor at the Department of Molecular Biology, Faculty of Science, The University of Zagreb
2017-223   Associate professor at the Department of Molecular Biology, Faculty of Science, The University of Zagreb

2023- now Full professor at the Department of Molecular Biology, Faculty of Science, The University of Zagreb

MEMBERSHIPS:

The Croatian Society for Genetics
The Croatian Society for Biochemistry
The Federation of European Biochemical Society
The Croatian Society for Biology
The Croatian Society of Molecular Engineers

THE MAIN FIELDS OF RESEARCH:

Genetics of DNA repair, homologous recombination and CRISPR-Cas antiviral mechanism in Escherichia coli

AWARDS:

In 2003, awarded by Croatian Genetic Society award “Željko Trgovčević” for young scientists and the Annual state award for natural sciences in 2018

TEACHING:

Molecular genetics for undergraduate students of Molecular biology and graduate students of Biochemistry
Introduction to molecular biology for students of integrated study of Biology and Chemistry
Genetic recombination and DNA repair for doctorate students of Biology

 

Published papers recorded in the Croatian Scientific Bibliography Database

Note: this list of papers is located in an maintained by the Ruđer Bošković Institute which is in charge of the Croatian Scientific Bibliography Database (CROSBI). This link will take you to the appropriate CROSBI page of this person, containing a list of papers they have themselves entered in the database.

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List of select publications

1. Killelea T., J. Dimude, H. Liu, F. Kemm, A. Stewart, I. Ivančić-Baće, M. Radovčić, C. Rudolph, E. L. Bolt (2023) Cas1-Cas2 physically and functionally interacts with DnaK to modulate CRISPR adaptation, Nucleic Acids Res 51: 6914-6926. https://doi.org/10.1093/nar/gkad473
2. Liu H, Jelić Matošević Z, Mitić D, Markulin D, Killelea T, Matković M, Bertoša B, Ivančić-Baće I, Bolt EL (2021) A Tryptophan ‘Gate’ in the CRISPR-Cas3 Nuclease Controls ssDNA Entry into the Nuclease Site, That When Removed Results in Nuclease Hyperactivity// Int J Mol Sci 22: 2848
3. Liu H, James M. SJ, Radovcic M, Ivancic-Bace I, Bolt EL (2020) Cas3 Protein—A Review of a Multi-Tasking Machine// Genes 11 (2), 208
4. Mitić D, Radovčić M, Markulin D, Ivančić-Baće I (2020) StpA represses CRISPR-Cas immunity in H-NS deficient Escherichia coli// Biochimie 174, 136-143
5. Radovčić M, Čulo A, Ivančić-Baće I (2019) Cas3-stimulated runaway replication of modified ColE1 plasmids in Escherichia coli is temperature dependent // FEMS microbiology letters, 366, fnz106, 7 doi:10.1093/femsle/fnz106.
6. Radovčić M., Killelea T., Savitskaya E., Wettstein L., Bolt E. L., Ivančić-Baće I. (2018) CRISPR-Cas adaptation in Escherichia coli requires RecBCD helicase but not nuclease activity, is independent of homologous recombination, and is antagonized by 5' ssDNA exonucleases. Nucleic Acids Res 46: 10173-10183
7. Majsec K., Bolt E. L., Ivančić-Baće I. (2016) Cas3 is a limiting factor for CRISPR-Cas immunity in Escherichia coli cells lacking H-NS. BMC Microbiol 16:643
8. Ivančić-Baće I., S. D. Cass, S. J. Wearne, E. L. Bolt (2015) Different genome stability proteins underpin primed and naïve adaptation in E. coli CRISPR-Cas immunity. Nucleic Acids Res. 43: 10821-10830
    

 

List of select projects

1. Project leader "How is CRISPR adaptation tuned to environment conditions? Mechanism from DNA helicases". IP-2022-10-7882 (2023-2027), financed by Croatian Science Foundation
2. Co-worker on the project „Building CRISPR Immunity Systems – How is Invading DNA Captured?“ (2020-2023), voditelja dr. sc. Edward L. Bolt,  projekt financiran od strane BBSRC, United Kingdom
3. Project leader “Cas3 as a key checkpoint for CRISPR-Cas immunity: elucidating it's regulation via protein stability and transcriptional control in Escherichia coli” (2017-2021) financed by Croatian Science Foundation
4. Co-worker on the project “CRISPR Adaptation - the basis for prokaryotic adaptive immunity” (2015-2018), financed by BBSRC, United Kingdom