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Plant Bioactive Compounds

Code: 44411
ECTS: 6.0
Lecturers in charge: prof. dr. sc. Gordana Rusak
Lecturers: Daria Gmižić , mag. oecol. - Practicum
izv. prof. dr. sc. Ivana Šola - Practicum
Take exam: Studomat
English level:


All teaching activities will be held in Croatian. However, foreign students in mixed groups will have the opportunity to attend additional office hours with the lecturer and teaching assistants in English to help master the course materials. Additionally, the lecturer will refer foreign students to the corresponding literature in English, as well as give them the possibility of taking the associated exams in English.

1. komponenta

Lecture typeTotal
Lectures 30
Practicum 30
* Load is given in academic hour (1 academic hour = 45 minutes)
1. Comprehend the importance of plant chemical substances and their potential for human health protection and disease treatment
2. Characterize the main groups of plant bioactive substances and identify them based on their chemical structure
3. Relate chemical structures of plant substances with plants that contain them
4. Understand the principles of herbal medicines effects on human health
5. Link action and potential risks of herbal preparations, alone or in combination with other vegetable and/or synthetic drugs
6. Create tea blends for treatment of specific ailments/diseases based on understanding the principle of each component effect.

1. Heterosides: phenolic (salicin, arbutin), cardiac (digitoksigenin, gitoksigenin, gitaloksigenin), saponins (escin, ginsenosides), flavonoids (referring to quercetin, its effects on cell cycle, on the synthesis of hsp proteins, proliferation and apoptosis of tumor cells, its antioxidative propertiesas as well as synergistic effects of quercetin with some cytostatica and its interaction with RNA, DNA and some enzymes in human cells) antraquinonic (frangulin, emodin), kumarinic (unsubstituited and condensed)
2. Alkaloids (hashish, opium, alkaloids from Atropa belladona);
3. Biogenic compounds in the tumour therapy (alkaloidis from Vinca, quercetin, propolis)
4. Biogenic imunostimulans and imunosupresives
Chemical structures of mentioned classes of plant bioactive substances as well as their in vitro and in vivo biological effects and potential risk in the therapy will be presented. Molecular mechanisms of their effects will be pointed out.

PRACTICUM (condensed schedule):
1. HPLC analysis of phenolic compounds
a) introduction to extraction methods
b) analysis implementation
c) preparation of calibration curves for determination of substances concentration
d) determination of substances concentration
e) isolation of the phenolic compounds of interest
2. Spectrophotometric determination of phenolic substances content
  1. Kerry Bone, Simon Mills (2013): Principles and practice of phytotherapy: Modern herbal medicine, 2e.
  2. Jutta Ludwig-Müller, Herwig Gutzeit (2014): Biologie von Naturstoffen.
2. semester
Izborni predmeti - Regular module - Botany
Izborni predmeti - Regular study - Molecular Biology

8. semester
Izborni predmeti biologija i /ili kemija - Regular study - Biology and Chemistry Education
Consultations schedule: