1. komponenta

Lecture type	Total
Lectures	30
Practicum	15
Seminar	15

* Load is given in academic hour (1 academic hour = 45 minutes)

COURSE AIM:
The Medical Genetics course provides an understanding of the genetic mechanisms underlying disease development by integrating knowledge from genetics, immunology, physiology, and cell biology. Students will analyse the basis of specific diseases affecting different organ systems and develop the best approaches for studying these diseases. Special emphasis is given to ethical principles in research and compliance with national and international laws and directives. The course also prepares students to plan laboratory experiments while optimizing resources and assessing the reliability of results.

COURSE CONTENT:
LECTURES
1) Genetic inheritance, causes of mutations, types of mutations
2) Association of genetic aberrations and disease development
3) Genetics of reproductive and developmental processes
4) Genetic aberrations during development
5) Genetics of infectious diseases and its impact of host cells
6) Immunogenetics
7) Immunodeficiencies, transplantation
8) Autoimmune diseases and hypersensitivity reactions
9-10) Genetic basis of malignant diseases
11) Genetics of mental disorders
12) Sample types in biomedicine
13) Types of studies in human genetics and biomarker evaluation
14) Development of new therapies
15) Biomedical ethics

SEMINARS
1) Types of biomedical research
2) Clinical aspects of disease
3) Interpretation of experiments

LABORATORY PRACTICE
1) DNA isolation from archival tissue
2) Staining of histological slides and analysis of tumor tissue
3) Gene expression analyses
4) Immunocytochemical staining
5) Fluorescence in situ hybridization

1. Rasko I i Downes CS: Genes in Medicine, Chapman & Hall, 1995
2. Strachan T i Read A: Human molecular genetics, Garland Science, 2011

Izborni predmeti - Genetika - Regular study - Molecular Biology