Sokhna Souare iz Laboratoire Sciences et Méthodes Séparatives (SMS Laboratory), University of Rouen Normandy, Francuska održat će u utorak 27. listopada u predavaonici 023 (prizemlje zgrade Kemije, Horvatovac 102a) s pocetkom u 11:00 sati kolokvij pod naslovom Enantioresolution of rac-phenprocoumon by diastereoisomeric salt formation. 

Sažetak:

Due to the antagonistic effects that enantiomers of a racemic compound can have, their separation becomes more than necessary. This study explores the method of chiral resolution by diastereoisomeric salt formation, a technique based on the reaction of a racemic mixture with a chiral agent to precipitate salts with different physicochemical properties such as solubility. Based on these differences, an efficient separation can therefore be carried out by selective crystallization. The experimental study was conducted on phenprocoumon with the chiral bases Quinine and Quinidine. The results yielded salts of R-phen + Qn2 and S- phen + Qdn which, upon acidification, demonstrated enantiomeric excess (ee) values of 100% for R and S respectively, as confirmed by HPLC analysis. This method proved to be adapted to the system studied and highlighted the influence of the ratio, solvent and temperature used in the efficiency of chiral resolution.