| Zvanje: | docent |
| Lokacija: | -029 |
| Telefon: | +385 1 4606 377 |
| Telefon kućni: | 6377 |
| E-mail: | |
| Zavod/služba: | Zavod za opću i anorgansku kemiju |
| Godina diplomiranja: | 2009. |
| Godina doktoriranja: | 2016. |
| Na zavodu od: | 2011. |
prijediplomski
diplomski
integrirani prijediplomski i diplomski
Diplomirala (2009.) na PMF-u u Zagrebu. Od 2011.-2016. radila je kao znanstveni novak na Zavodu za Opću i anorgansku kemiju Kemijskog Odsjeka PMF-a, a od prosinca 2016. do prosinca 2022. kao poslijedoktorand pri Zavodu za Opću i anorgansku kemiju Kemijskog Odsjeka PMF-a. Od siječnja 2023. zaposlena je kao docent. Kao znanstvenik gostovala je na University of Padua, Department of Biomedical Sciences (Italija). Doktorirala je 2016. na PMF-u u Zagrebu.
Bavi se kloniranjem, ekspresijom, pročišćavanjem i kristalizacijom proteina te kristalografijom proteina, DNA i malih molekula. U svom znanstvenom radu bavi se karakterizacijom proteina biofizikalnim metodama (CD, DLS, UV-VIS spektrofotomertrija, fluorimetrija) i određivanjem trodimenzionalne strukture proteina.
Znanstvene publikacije: https://www.croris.hr/crosbi/searchByContext/2/30194
Sudjeluje kao nositelj i izvođač u nastavi iz kolegija opće i anorganske kemije.
2009. dodijeljena joj je medalja Kemijskog odsjeka za izvrstan uspjeh tijekom studiranja.
Članica je HKD i HKZ.
The Thirtieth Croatian-Slovenian Crystallographic Meeting
Disulfide bond enables cytosolic protein to function in oxidizing conditions
Evolutionarily conserved cysteines in plant cytosolic seryl-tRNA synthetase are important for its resistance to oxidation
Exploring the copper affinity toward the CrdA protein from Helicobacter pylori
Crystallization of the Keap1-DPP III complex
Uloga disulfidne veze u biljnoj citosolnoj seril-tRNA-sintetazi
Binding of peptide mimicking the ETGE loop of dipeptidyl peptidase III to the Kelch domain of Keap1
Contrasting effect of evolutionary conserved cysteines on the stability of plant seryl-tRNA synthetase
Copper Binding and Oligomerization Studies of the Metal Resistance Determinant CrdA from Helicobacter pylori
Counter anion effects on the formation and structural transformations of mo(vi)-hydrazone coordination assemblies: salts, solvates, co- crystals, and neutral complexes
Zn(II) halide coordination compounds with imidazole and 2-methylimidazole. Structural and computational characterization of intermolecular interactions and disorder
Emerging noncanonical functions of plant aminoacyl- tRNA synthetase
Binding of dipeptidyl peptidase III to the oxidative stress cell sensor Kelch-like ECH- associated protein 1 is a two-step process
Importance of the disulfide link in the stability of cytosolic protein
Comprehensive study on molybdenum(VI) complexes of 3-methoxysalicylaldehyde isonicotinoylhydrazone
Utjecaj halogenidnih iona na kristalizaciju te molekulsku i kristalnu strukturu bakrovog(II),niklovog(II) i kobaltovog(II) derivata ljudskog inzulina
Strukturno istraživanje uloge disulfidne veze u seril-tRNA-sintetazi iz biljke Arabidopsis thaliana (RAD ZA REKTOROVU NAGRADU)
Kristalizacija derivata inzulina
Plant seryl-tRNA synthetase as a link between translation and metabolism of brassinosteroid hormones
Plant seryl-tRNA synthetase as a link between translation and metabolism of brassinosteroid hormones
Određivanje interakcije bakrovih iona i proteina CrdA iz bakterije Helicobacter pylori
Stability studies of selected Helicobacter pylori proteins required for survival
Arabidopsis seryl-tRNA synthetase: the first crystal structure and novel protein interactor of plant aminoacyl-tRNA synthetase
Phenylboronic Acids Probing Molecular Recognition against Class A and Class C β-lactamases
Where translation meets plant steroid metabolism: interaction of seryl-tRNA synthetase and BEN1 protein from Arabidopsis thaliana
Pojačana ekspresija i kristalizacija proteina HP1026 iz bakterije Helicobacter pylori
Copper(II) complexes with N-alkyliminodiacetamide ligands. Preparation, structural, spectroscopic and DFT studies and biological evaluation
Pojačana ekspresija, pročišćavanje i kristalizacija proteina CrdA te optimizacija kristalizacije proteina HP1026 iz bakterije Helicobacter pylori
Crystallization of putative copper binding CrdA protein and helicase-like HP1026 protein from the human pathogen Helicobacter pylori
Revealing the structure of the first plant aminoacyl-tRNA synthetase at 2.3 Å
Influence of the non-coordinating alkyl chain type in N-alkylated iminodiacetamides on the stability and structure of their complexes with nickel(II) and cobalt(II)
Structural characterization of FlgE2 protein from Helicobacter pylori hook
The first crystal structure of plant aminoacyl-tRNA synthetase: seryl-tRNA synthetase from Arabidopsis thaliana
Stability data of FlgD from Helicobacter pylori and structural comparison with other homologs
Crystal structure of truncated FlgD from the human pathogen Helicobacter pylori
Structure and Stability of FlgD from the Pathogenic 26695 Strain of Helicobacter pylori
Structural characterization of Heliobacter plyori proteinsrequired for survival of the bacterium
Stabilnost i strukturna karakterizacija proteina FlgD iz bakterije Helicobacter pylori
Reakcije niklovih(II) i kobaltovih(II) soli s derivatima iminodiacetamida
Biološki aktivni kompleksi bakra(II) s N-alkilnim derivatima iminodiacetamida
Kloniranje i ekspresija različitih varijanti HP1326 iz bakterije Helicobacter pylori
Crystal Structure of Truncated FlgD from the Human Pathogen Helicobacter pylori
CHARACTERIZATION OF CrdA - THE COPPER HOMEOSTASIS FACTOR FROM BACTERIUM HELICOBACTER PYLORI
Synthesis and structural studies of dioxomolybdenum(VI) complexes with isoniazid- related hydrazones
Dioxidomolybdenum(VI) complexes with isoniazid- related hydrazones: solution-based, mechanochemical and UV-light assisted deprotonation†
Kompleksi Co(II), Ni(II) i Cu(II) s N- cikloheksiliminodiacetamidom
Crystal structure of truncated FlgD from the human pathogen Helicobacter pylori
Structural Characterization at the Atomic Level of a Molecular Nano-Machine: The State of the Art of Helicobacter Pylori Flagellum Organization
Structural studies of FlgD - flagella hook capping protein from Helicobacter pylori
Structural and functional characterization of ATP binding HP1026 - Helicobacter pylori heat shock protein
Structural Characterization of the Metal Homeostasis Factors from Helicobacter Pylori
Spectroscopic and structural insights into N- substituted pyridinium-4-aldoximes and their pentacyanoferrate(II) complexes
Cloning, purification and crystallization of FlgD and CrdA – Helicobacter pylori survival required proteins
Crystallization of Insulin Derivatives
Structural studies about HypB and CrdA, two Helicobacter pylori metal homeostasis key factors
High Resolution Structure of the Manganese Derivative of Insulin
Kristalna struktura vanadijevog derivata inzulina
High resolution structure of the Mn derivative of insulin
Metode istraživanja u obrazovanju (razredbeni ispiti iz kemije)
Izučavanje reakcije hesperetina i titanija(IV) spektrofotometrijskom metodom
V. Ević, R. Šoić, Ruzica, M. Močibob, M. Kekez, J. Houser, M. Wimmerova, D. Matković-Čalogović, I. Gruić-Sovulj, I. Kekez, J. Rokov-Plavec. Evolutionarily conserved cysteines in plant cytosolic seryl-tRNA synthetase are important for its resistance to oxidation. FEBS Lett., 597 (23) (2023), 2975-2992.
I. Kekez, M. Faletar, M. Kekez, L. Cendron, M. Wright, G. Zanotti, D. Matković-Čalogović. Copper Binding and Oligomerization Studies of the Metal Resistance Determinant CrdA from Helicobacter pylori. Molecules, 27 (11) (2022), 3387.
S. Matić, I. Kekez, M. Tomin, F. Bogár, F. Šupljika, S. Kazazić, M. Hanić, S. Jha, H. Brkić, B. Bourgeois, M. Tobias, K. Gruber, P. Macheroux, D. Matković-Čalogović, M. Matovina, S. Tomić. Binding of dipeptidyl peptidase III to the oxidative stress cell sensor Kelch-like ECH-associated protein 1 is a two-step process. J. Biomol. Struct. Dyn. (2020)
P. Linciano, M. Vicario, I. Kekez, P. Bellio, G. Celenza, I. Martín-Blecua, J. Blázquez, L. Cendron, D. Tondi. Phenyl boronic acids probing molecular recognition against class A and class C β-lactamases. Antibiotics. 8 (4) (2019), 171.
M. Kekez, V. Zanki, I. Kekez, J. Baranašić, V. Hodnik, A.-M. Duchêne, G. Anderluh, I. Gruić Sovulj, D. Matković-Čalogović, I. Weygand- Đurašević, J. Rokov Plavec. Arabidopsis seryl-tRNA synthetase: the first crystal structure and novel protein interactor of plant aminoacyl-tRNA synthetase. FEBS J., 286 (3) (2019) 536-554.
V. Loconte, I. Kekez, D. Matković-Čalogović, G. Zanotti. Structural characterization of FlgE2 protein from Helicobacter pylori hook. FEBS J., 284 (24) (2017) 4328-4342.
I. Pulić, L. Cendron, M. Salamina, P. Polverino de Laureto, D. Matković-Čalogović, G. Zanotti. Crystal structure of truncated FlgD from the human pathogen Helicobacter pylori. J. Struct. Biol. 194 (2) (2016) 147-155.
Suradnik na projektu:
Razvojne istraživačke potpore, Nacionalni plan oporavka i otpornosti, Next Generation EU: ”Enzimsko inženjerstvo za održivo recikliranje bioplastike“, NPOO.C3.2.R2-I1.06 (2023–2026);
Hrvatska zaklada za znanost, Republika Hrvatska, projekt: “Biološka važnost dipeptidil peptidaze III i njezin utjecaj na zdravlje čovjeka", HRZZ- IP-2018-01-2936 (2019-2023);
Hrvatska zaklada za znanost, Republika Hrvatska, projekt: “Esencijalni metalni ioni u proteinima iz Helicobacter pylori i modelnim spojevima - struktura i funkcija/svojstvo", HRZZ-IP-2014-09-4274 (2015-2019);
Hrvatska akademija znanosti i umjetnosti, Republika Hrvatska, projekt: "Kristalizacija i strukturna istraživanja derivata ljudskog inzulina i proteina HP1026 iz bakterije Helicobacter pylori" (2016-2017);
PRIN 2010-2011, Republika Italija, projekt: “Unraveling structural and functional determinants behind Helicobacter pylori pathogenesis and persistence” (2013-2014);
Stipendija za doktorande Hrvatske zaklade za znanost, Republika Hrvatska, projekt: "Structural studies on the [NiFe]hydrogenase maturation system from Helicobacter pylori” (2012);
Ministarstvo znanosti i obrazovanja, Republika Hrvatska, projekt: “Strukturno istraživanje bioloških makromolekula metodom rentgenske difrakcije” (2011-2013).
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